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apotome epifluorescence microscope with structured illumination hardware and deconvolution software  (Carl Zeiss)


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    Carl Zeiss apotome epifluorescence microscope with structured illumination hardware and deconvolution software
    a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
    Apotome Epifluorescence Microscope With Structured Illumination Hardware And Deconvolution Software, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/apotome+epifluorescence+microscope+with+structured+illumination+hardware+and+deconvolution+software/epifluorescence+microscope/bio_rxiv__2024__03__15__585251-260-20-22
    Average 90 stars, based on 1 article reviews
    apotome epifluorescence microscope with structured illumination hardware and deconvolution software - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Lesion-remote astrocytes govern microglia-mediated white matter repair"

    Article Title: Lesion-remote astrocytes govern microglia-mediated white matter repair

    Journal: bioRxiv

    doi: 10.1101/2024.03.15.585251

    a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in deconvolution of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
    Figure Legend Snippet: a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in deconvolution of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.

    Techniques Used: Comparison, RNA Sequencing, Gene Expression, Expressing

    Related Articles

    Microscopy:

    Article Title: Lesion-remote astrocytes govern microglia-mediated white matter repair
    Article Snippet: .. Images of tissue sections used for quantitative analyses were collected using an Apotome epifluorescence microscope with structured illumination hardware and deconvolution software (Zeiss). ..

    Software:

    Article Title: Lesion-remote astrocytes govern microglia-mediated white matter repair
    Article Snippet: .. Images of tissue sections used for quantitative analyses were collected using an Apotome epifluorescence microscope with structured illumination hardware and deconvolution software (Zeiss). ..



    Similar Products

    apotome epifluorescence microscope with structured illumination hardware and deconvolution software  (Carl Zeiss)
    90
    Carl Zeiss apotome epifluorescence microscope with structured illumination hardware and deconvolution software
    a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in <t>deconvolution</t> of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.
    Apotome Epifluorescence Microscope With Structured Illumination Hardware And Deconvolution Software, supplied by Carl Zeiss, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/apotome+epifluorescence+microscope+with+structured+illumination+hardware+and+deconvolution+software/epifluorescence+microscope/bio_rxiv__2024__03__15__585251-260-20-22
    Average 90 stars, based on 1 article reviews
    apotome epifluorescence microscope with structured illumination hardware and deconvolution software - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in deconvolution of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.

    Journal: bioRxiv

    Article Title: Lesion-remote astrocytes govern microglia-mediated white matter repair

    doi: 10.1101/2024.03.15.585251

    Figure Lengend Snippet: a , Comparison of SCI BFAs and hypertrophic reactive LRAs after iSCI. b , SCI LRA RiboTag RNA-Seq schematic. c , d, Bar graph and upset plot illustrating LRA RiboTag RNA-Seq DEGs over time after iSCI, vs Healthy (FDR P ≤ 0.01) (n=4-6 mice/genotype/group). Rostral and caudal data are combined. e , Identification of temporally co-regulated LRA-enriched gene modules by Spearman correlation analysis. f , g , Line graphs illustrating temporally regulated gene expression of example LRA co-regulated gene modules with heat map of respective astrocyte relevant and enriched gene ontology terms. Temporal regulation patterns for rostral (red) and caudal (blue) are illustrated independently. ( P ≤ 0.05, ** P ≤ 0.002, *** P ≤ 0.0002, **** P ≤ 0.0001Two-way ANOVA with Tukeys). h , Schematic of combined snRNA-Seq and spatial transcriptomics approach for interrogating SCI reactive LRAs and neighboring cell types. i , UMAP of spinal cord cell types identified by snRNA-Seq for healthy and all post-injury time points, rostral and caudal (n=4-6 mice/timepoint/region). j , Diagram of intraspinal regions used in deconvolution of spatial transcriptomic data (n=4 mice/timepoint/region). k , UMAP constellation plot of healthy and iSCI astrocytes illustrating neuroanatomically restricted LRA subtypes and their distinct molecular states. l , Spatial transcriptomic characterization of vGM3 astrocytes illustrates restricted positioning in ventral horn grey matter. m , High magnification of vGM3 markers Arex and Thrsp in Gfap + / Aldoc + ventral horn grey matter astrocytes . n , Spatial transcriptomic characterization of WM4 astrocytes illustrates restricted unilateral white matter expression. o , High magnification of vGM3 markers shows unilateral expression of Glipr2 and Ccn1 in Gfap + / Aldoc + white matter astrocytes . p , Heat map showing relative expression of functionally related genes across regionally restricted LRA molecular states. Scale bar, 10 µm.

    Article Snippet: Images of tissue sections used for quantitative analyses were collected using an Apotome epifluorescence microscope with structured illumination hardware and deconvolution software (Zeiss).

    Techniques: Comparison, RNA Sequencing, Gene Expression, Expressing